Is the microRNA-221/222 Cluster Ushering in a New Age of Cardiovascular Diseases?

نویسندگان

چکیده

Kromě regulace genovĂŠ exprese regulujĂ­ krĂĄtkĂŠ nekĂłdujĂ­cĂ­ molekuly RNA (microR, miR) rychlost degradace a translace informačnĂ­ (messenger RNA). KrĂĄtkĂŠ miR vykazujĂ­ vysokou expresi v kardiovaskulĂĄrnĂ­m (KV) systĂŠmu, coĹž ukazuje na jejich vĂ˝znamnou Ăşlohu ve vaskulĂĄrnĂ­m zdravĂ­. Proces vzniku rozvoje aterosklerĂłzy je dĂĄvĂĄn do souvislosti s miR-221 -222. miR-221/222 pĹŻsobĂ­ proti stenĂłz mohou potenciĂĄlně slouĹžit jako marker remodelace myokardu. Přesto jeĹĄtě potrvĂĄ dlouho, neĹž bude moĹžno povaĹžovat moĹžnĂ˝ cĂ­l léčby. Identifikace, ověřenĂ­ poznĂĄnĂ­ funkcĂ­ genovĂ˝ch cĂ­lĹŻ, vĹĄechny tyto procesy jsou nesmĂ­rně dĹŻleĹžitĂŠ. © 2023, ČKS.

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ژورنال

عنوان ژورنال: Cor et vasa

سال: 2023

ISSN: ['0010-8650', '1803-7712']

DOI: https://doi.org/10.33678/cor.2022.050